A Novel Method for Sampling Alpha-helical Protein Backbones
نویسندگان
چکیده
منابع مشابه
A novel method for sampling alpha-helical protein backbones.
We present a novel technique of sampling the configurations of helical proteins. Assuming knowledge of native secondary structure, we employ assembly rules gathered from a database of existing structures to enumerate the geometrically possible three-dimensional arrangements of the constituent helices. We produce a library of possible folds for 25 helical protein cores. In each case, our method ...
متن کاملHMM_RA: An Improved Method for Alpha-Helical Transmembrane Protein Topology Prediction
alpha-helical transmembrane (TM) proteins play important and diverse functional roles in cells. The ability to predict the topology of these proteins is important for identifying functional sites and inferring function of membrane proteins. This paper presents a Hidden Markov Model (referred to as HMM_RA) that can predict the topology of alpha-helical transmembrane proteins with improved perfor...
متن کاملA Novel Method for Travel System Patterns
Due to population growth in urban areas, especially in the capital cities in developing countries, the use of private vehicles are increasing, leading to many problems such as congestion, pollution, noise, long travel time, high travel cost and more side effects. In such circumstances government policy would encourage people to use public transportation. In the meantime, employing the Intellige...
متن کاملA novel local search method for microaggregation
In this paper, we propose an effective microaggregation algorithm to produce a more useful protected data for publishing. Microaggregation is mapped to a clustering problem with known minimum and maximum group size constraints. In this scheme, the goal is to cluster n records into groups of at least k and at most 2k_1 records, such that the sum of the within-group squ...
متن کاملA Novel Method for Skin Lesion Segmentation
Skin cancer has been the most usual and illustrates 50% of all new cancers detected each year. If they detected at an early stage, treatment can become simple and economically. Accurate skin lesion segmentation is important in automated early skin cancer detection and diagnosis systems. The aim of this study is to provide an effective approach to detect the skin lesion border on a purposed imag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2001
ISSN: 0022-2836
DOI: 10.1006/jmbi.2000.4290